EVOLUTION-MANAGER
Edit File: udca.html
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Strict//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-strict.dtd"><html xmlns="http://www.w3.org/1999/xhtml"><head><title>R: Data from a trial of usrodeoxycholic acid</title> <meta http-equiv="Content-Type" content="text/html; charset=utf-8" /> <link rel="stylesheet" type="text/css" href="R.css" /> </head><body> <table width="100%" summary="page for udca {survival}"><tr><td>udca {survival}</td><td style="text-align: right;">R Documentation</td></tr></table> <h2>Data from a trial of usrodeoxycholic acid </h2> <h3>Description</h3> <p>Data from a trial of ursodeoxycholic acid (UDCA) in patients with primary biliary cirrohosis (PBC). </p> <h3>Usage</h3> <pre>data("udca")</pre> <h3>Format</h3> <p>A data frame with 170 observations on the following 15 variables. </p> <dl> <dt><code>id</code></dt><dd><p>subject identifier</p> </dd> <dt><code>trt</code></dt><dd><p>treatment of 0=placebo, 1=UDCA</p> </dd> <dt><code>entry.dt</code></dt><dd><p>date of entry into the study</p> </dd> <dt><code>last.dt</code></dt><dd><p>date of last on-study visit</p> </dd> <dt><code>stage</code></dt><dd><p>stage of disease</p> </dd> <dt><code>bili</code></dt><dd><p>bilirubin value at entry</p> </dd> <dt><code>riskscore</code></dt><dd><p>the Mayo PBC risk score at entry</p> </dd> <dt><code>death.dt</code></dt><dd><p>date of death</p> </dd> <dt><code>tx.dt</code></dt><dd><p>date of liver transplant</p> </dd> <dt><code>hprogress.dt</code></dt><dd><p>date of histologic progression</p> </dd> <dt><code>varices.dt</code></dt><dd><p>appearance of esphogeal varices</p> </dd> <dt><code>ascites.dt</code></dt><dd><p>appearance of ascites</p> </dd> <dt><code>enceph.dt</code></dt><dd><p>appearance of encephalopathy</p> </dd> <dt><code>double.dt</code></dt><dd><p>doubling of initial bilirubin</p> </dd> <dt><code>worsen.dt</code></dt><dd><p>worsening of symptoms by two stages</p> </dd> </dl> <h3>Details</h3> <p>This data set is used in the Therneau and Grambsh. The <code>udca1</code> data set contains the baseline variables along with the time until the first endpoint (any of death, transplant, ..., worsening). The <code>udca2</code> data set treats all of the endpoints as parallel events and has a stratum for each. </p> <h3>References</h3> <p>T. M. Therneau and P. M. Grambsch, Modeling survival data: extending the Cox model. Springer, 2000. </p> <p>K. D. Lindor, E. R. Dickson, W. P Baldus, R.A. Jorgensen, J. Ludwig, P. A. Murtaugh, J. M. Harrison, R. H. Weisner, M. L. Anderson, S. M. Lange, G. LeSage, S. S. Rossi and A. F. Hofman. Ursodeoxycholic acid in the treatment of primary biliary cirrhosis. Gastroenterology, 106:1284-1290, 1994. </p> <h3>Examples</h3> <pre> data(udca) # values found in table 8.3 of the book fit1 <- coxph(Surv(futime, status) ~ trt + log(bili) + stage + cluster(id), data=udca1) fit2 <- coxph(Surv(futime, status) ~ trt + log(bili) + stage + cluster(id) + strata(endpoint), data=udca2) </pre> <hr /><div style="text-align: center;">[Package <em>survival</em> version 2.44-1.1 <a href="00Index.html">Index</a>]</div> </body></html>