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<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Strict//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-strict.dtd"><html xmlns="http://www.w3.org/1999/xhtml"><head><title>R: Chemotherapy for Stage B/C colon cancer</title> <meta http-equiv="Content-Type" content="text/html; charset=utf-8" /> <link rel="stylesheet" type="text/css" href="R.css" /> </head><body> <table width="100%" summary="page for colon {survival}"><tr><td>colon {survival}</td><td style="text-align: right;">R Documentation</td></tr></table> <h2>Chemotherapy for Stage B/C colon cancer</h2> <h3>Description</h3> <p>These are data from one of the first successful trials of adjuvant chemotherapy for colon cancer. Levamisole is a low-toxicity compound previously used to treat worm infestations in animals; 5-FU is a moderately toxic (as these things go) chemotherapy agent. There are two records per person, one for recurrence and one for death</p> <h3>Usage</h3> <pre>colon</pre> <h3>Format</h3> <table summary="Rd table"> <tr> <td style="text-align: left;"> id:</td><td style="text-align: left;"> id</td> </tr> <tr> <td style="text-align: left;"> study:</td><td style="text-align: left;"> 1 for all patients</td> </tr> <tr> <td style="text-align: left;"> rx:</td><td style="text-align: left;"> Treatment - Obs(ervation), Lev(amisole), Lev(amisole)+5-FU</td> </tr> <tr> <td style="text-align: left;"> sex:</td><td style="text-align: left;"> 1=male</td> </tr> <tr> <td style="text-align: left;"> age:</td><td style="text-align: left;"> in years</td> </tr> <tr> <td style="text-align: left;"> obstruct:</td><td style="text-align: left;"> obstruction of colon by tumour</td> </tr> <tr> <td style="text-align: left;"> perfor:</td><td style="text-align: left;"> perforation of colon</td> </tr> <tr> <td style="text-align: left;"> adhere:</td><td style="text-align: left;"> adherence to nearby organs</td> </tr> <tr> <td style="text-align: left;"> nodes:</td><td style="text-align: left;"> number of lymph nodes with detectable cancer</td> </tr> <tr> <td style="text-align: left;"> time:</td><td style="text-align: left;"> days until event or censoring</td> </tr> <tr> <td style="text-align: left;"> status:</td><td style="text-align: left;"> censoring status</td> </tr> <tr> <td style="text-align: left;"> differ:</td><td style="text-align: left;"> differentiation of tumour (1=well, 2=moderate, 3=poor)</td> </tr> <tr> <td style="text-align: left;"> extent:</td><td style="text-align: left;"> Extent of local spread (1=submucosa, 2=muscle, 3=serosa, 4=contiguous structures)</td> </tr> <tr> <td style="text-align: left;"> surg:</td><td style="text-align: left;"> time from surgery to registration (0=short, 1=long)</td> </tr> <tr> <td style="text-align: left;"> node4:</td><td style="text-align: left;"> more than 4 positive lymph nodes</td> </tr> <tr> <td style="text-align: left;"> etype:</td><td style="text-align: left;"> event type: 1=recurrence,2=death</td> </tr> <tr> <td style="text-align: left;"> </td> </tr> </table> <h3>Note</h3> <p>The study is originally described in Laurie (1989). The main report is found in Moertel (1990). This data set is closest to that of the final report in Moertel (1991). A version of the data with less follow-up time was used in the paper by Lin (1994). </p> <h3>References</h3> <p>JA Laurie, CG Moertel, TR Fleming, HS Wieand, JE Leigh, J Rubin, GW McCormack, JB Gerstner, JE Krook and J Malliard. Surgical adjuvant therapy of large-bowel carcinoma: An evaluation of levamisole and the combination of levamisole and fluorouracil: The North Central Cancer Treatment Group and the Mayo Clinic. J Clinical Oncology, 7:1447-1456, 1989. </p> <p>DY Lin. Cox regression analysis of multivariate failure time data: the marginal approach. Statistics in Medicine, 13:2233-2247, 1994. </p> <p>CG Moertel, TR Fleming, JS MacDonald, DG Haller, JA Laurie, PJ Goodman, JS Ungerleider, WA Emerson, DC Tormey, JH Glick, MH Veeder and JA Maillard. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. New England J of Medicine, 332:352-358, 1990. </p> <p>CG Moertel, TR Fleming, JS MacDonald, DG Haller, JA Laurie, CM Tangen, JS Ungerleider, WA Emerson, DC Tormey, JH Glick, MH Veeder and JA Maillard, Fluorouracil plus Levamisole as an effective adjuvant therapy after resection of stage II colon carcinoma: a final report. Annals of Internal Med, 122:321-326, 1991. </p> <hr /><div style="text-align: center;">[Package <em>survival</em> version 2.44-1.1 <a href="00Index.html">Index</a>]</div> </body></html>