EVOLUTION-MANAGER
Edit File: Indometh.html
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Strict//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-strict.dtd"><html xmlns="http://www.w3.org/1999/xhtml"><head><title>R: Pharmacokinetics of Indomethacin</title> <meta http-equiv="Content-Type" content="text/html; charset=utf-8" /> <link rel="stylesheet" type="text/css" href="R.css" /> </head><body> <table width="100%" summary="page for Indometh {datasets}"><tr><td>Indometh {datasets}</td><td style="text-align: right;">R Documentation</td></tr></table> <h2>Pharmacokinetics of Indomethacin</h2> <h3>Description</h3> <p>The <code>Indometh</code> data frame has 66 rows and 3 columns of data on the pharmacokinetics of indometacin (or, older spelling, ‘indomethacin’). </p> <h3>Usage</h3> <pre>Indometh</pre> <h3>Format</h3> <p>An object of class <code>c("nfnGroupedData", "nfGroupedData", "groupedData", "data.frame")</code> containing the following columns: </p> <dl> <dt>Subject</dt><dd> <p>an ordered factor with containing the subject codes. The ordering is according to increasing maximum response. </p> </dd> <dt>time</dt><dd> <p>a numeric vector of times at which blood samples were drawn (hr). </p> </dd> <dt>conc</dt><dd> <p>a numeric vector of plasma concentrations of indometacin (mcg/ml). </p> </dd> </dl> <h3>Details</h3> <p>Each of the six subjects were given an intravenous injection of indometacin. </p> <p>This dataset was originally part of package <code>nlme</code>, and that has methods (including for <code>[</code>, <code>as.data.frame</code>, <code>plot</code> and <code>print</code>) for its grouped-data classes. </p> <h3>Source</h3> <p>Kwan, Breault, Umbenhauer, McMahon and Duggan (1976) Kinetics of Indomethacin absorption, elimination, and enterohepatic circulation in man. <em>Journal of Pharmacokinetics and Biopharmaceutics</em> <b>4</b>, 255–280. </p> <p>Davidian, M. and Giltinan, D. M. (1995) <em>Nonlinear Models for Repeated Measurement Data</em>, Chapman & Hall (section 5.2.4, p. 129) </p> <p>Pinheiro, J. C. and Bates, D. M. (2000) <em>Mixed-effects Models in S and S-PLUS</em>, Springer. </p> <h3>See Also</h3> <p><code><a href="../../stats/html/SSbiexp.html">SSbiexp</a></code> for models fitted to this dataset. </p> <hr /><div style="text-align: center;">[Package <em>datasets</em> version 3.6.0 <a href="00Index.html">Index</a>]</div> </body></html>